000			02130 am a22002773u 4500
042			_adc
100	1	0	_aHaseeb, Syed _eauthor _9373
700	1	0	_aKariyanna, Pramod Theetha _eauthor _9374
700	1	0	_aJayarangaiah, Apoorva _eauthor _9375
700	1	0	_aThirunavukkarasu, Ganesh _eauthor _9376
700	1	0	_aHegde, Sudhanva _eauthor _9377
700	1	0	_aMarmur, Jonathan D. _eauthor _9378
700	1	0	_aNeurgaonkar, Sneha _eauthor _9379
700	1	0	_aMcFarlane, Samy I. _eauthor _9380
245	0	0	_aBrugada Pattern in Diabetic Ketoacidosis: A Case Report and Scoping Study
260			_c2018.
500			_a/pmc/articles/PMC6282764/
500			_a/pubmed/30533520
520			_aBrugada syndrome is a rare cardiac arrhythmia which is associated with right bundle branch block pattern (RBBB) and ST-segment elevation in right precordial leads. SCNA5 mutation is the most common genetic abnormality associated with Brugada syndrome. Brugada pattern not related to genetic mutations has been previously reported in the setting of fever, metabolic conditions, lithium use, marijuana and cocaine abuse, ischemia and pulmonary embolism, myocardial and pericardial diseases. Multiple isolated cases of Brugada pattern associated with diabetic ketoacidosis (DKA) have been previously reported. We here present a case of type 1 Brugada pattern in a 23 year-old-male who presented with DKA. Brugada pattern in DKA is attributed to acidosis and multiple electrolyte abnormalities including hyperkalemia which alter ion channel expression in the heart thus leading to Brugada pattern which subsequently resolved with treatment of DKA. In such patients, Brugada pattern is not reproducible on procainamide induction cardiac electrophysiology study (EPS). Our scoping study demonstrates male predominance 20/22 cases of (DELETE this highlighted area) Brugada pattern in DKA, a finding that is consistent with prevalence of this disease among males.
540			_a
546			_aen
690			_aArticle
655	7		_aText _2local
786	0		_nAm J Med Case Rep
856	4	1	_uhttp://dx.doi.org/10.12691/ajmcr-6-9-2 _zConnect to this object online.
999			_c614 _d614