| 000 | 03202 am a22006373u 4500 | ||
|---|---|---|---|
| 042 | _adc | ||
| 100 | 1 | 0 |
_aManfredi-Lozano, Maria _eauthor _91529 |
| 700 | 1 | 0 |
_aLeysen, Valerie _eauthor _91530 |
| 700 | 1 | 0 |
_aAdamo, Michela _eauthor _91531 |
| 700 | 1 | 0 |
_aPaiva, Isabel _eauthor _91532 |
| 700 | 1 | 0 |
_aRovera, Renaud _eauthor _91533 |
| 700 | 1 | 0 |
_aPignat, Jean-Michel _eauthor _91534 |
| 700 | 1 | 0 |
_aTimzoura, Fatima Ezzahra _eauthor _91535 |
| 700 | 1 | 0 |
_aCandlish, Michael _eauthor _91536 |
| 700 | 1 | 0 |
_aEddarkaoui, Sabiha _eauthor _91537 |
| 700 | 1 | 0 |
_aMalone, Samuel A. _eauthor _91538 |
| 700 | 1 | 0 |
_aSilva, Mauro S. B. _eauthor _91539 |
| 700 | 1 | 0 |
_aTrova, Sara _eauthor _91540 |
| 700 | 1 | 0 |
_aImbernon, Monica _eauthor _91541 |
| 700 | 1 | 0 |
_aDecoster, Laurine _eauthor _91542 |
| 700 | 1 | 0 |
_aCotellessa, Ludovica _eauthor _91543 |
| 700 | 1 | 0 |
_aTena-Sempere, Manuel _eauthor _91544 |
| 700 | 1 | 0 |
_aClaret, Marc _eauthor _91545 |
| 700 | 1 | 0 |
_aPaoloni-Giacobino, Ariane _eauthor _91546 |
| 700 | 1 | 0 |
_aPlassard, Damien _eauthor _91547 |
| 700 | 1 | 0 |
_aPaccou, Emmanuelle _eauthor _91548 |
| 700 | 1 | 0 |
_aVionnet, Nathalie _eauthor _91549 |
| 700 | 1 | 0 |
_aAcierno, James _eauthor _91550 |
| 700 | 1 | 0 |
_aMaceski, Aleksandra Maleska _eauthor _91551 |
| 700 | 1 | 0 |
_aLutti, Antoine _eauthor _91552 |
| 700 | 1 | 0 |
_aPfrieger, Frank _eauthor _91553 |
| 700 | 1 | 0 |
_aRasika, S. _eauthor _91554 |
| 700 | 1 | 0 |
_aSantoni, Federico _eauthor _91555 |
| 700 | 1 | 0 |
_aBoehm, Ulrich _eauthor _91556 |
| 700 | 1 | 0 |
_aCiofi, Philippe _eauthor _91557 |
| 700 | 1 | 0 |
_aBuée, Luc _eauthor _91558 |
| 700 | 1 | 0 |
_aHaddjeri, Nasser _eauthor _91559 |
| 700 | 1 | 0 |
_aBoutillier, Anne-Laurence _eauthor _91560 |
| 700 | 1 | 0 |
_aKuhle, Jens _eauthor _91561 |
| 700 | 1 | 0 |
_aMessina, Andrea _eauthor _91562 |
| 700 | 1 | 0 |
_aDraganski, Bogdan _eauthor _91563 |
| 700 | 1 | 0 |
_aGiacobini, Paolo _eauthor _91564 |
| 700 | 1 | 0 |
_aPitteloud, Nelly _eauthor _91565 |
| 700 | 1 | 0 |
_aPrevot, Vincent _eauthor _91566 |
| 245 | 0 | 0 | _aGnRH replacement rescues cognition in Down Syndrome |
| 260 | _c2022-09-02. | ||
| 500 | _a/pmc/articles/PMC7613827/ | ||
| 500 | _a/pubmed/36048943 | ||
| 520 | _aCurrently, no viable treatment exists for cognitive and olfactory deficits in Down syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive non-reproductive neurological symptoms closely parallel a post-pubertal decrease in hypothalamic as well as extra-hypothalamic expression of a master molecule controlling reproduction - gonadotropin-releasing hormone (GnRH), and appear related to an imbalance in a microRNA-gene network known to regulate GnRH neuron maturation together with altered hippocampal synaptic transmission. Epigenetic, cellular, chemogenetic and pharmacological interventions that restore physiological GnRH levels abolish olfactory and cognitive defects in Ts65Dn mice, while pulsatile GnRH therapy improves cognition and brain connectivity in adult DS patients. GnRH thus plays a crucial role in olfaction and cognition, and pulsatile GnRH therapy holds promise to improve cognitive deficits in DS. | ||
| 540 | _a | ||
| 546 | _aen | ||
| 690 | _aArticle | ||
| 655 | 7 |
_aText _2local |
|
| 786 | 0 | _nScience | |
| 856 | 4 | 1 |
_uhttp://dx.doi.org/10.1126/science.abq4515 _zConnect to this object online. |
| 999 |
_c324 _d324 |
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