| 000 | 01558 am a22002293u 4500 | ||
|---|---|---|---|
| 042 | _adc | ||
| 100 | 1 | 0 |
_aHarly, Christelle _eauthor _91172 |
| 700 | 1 | 0 |
_aRobert, Jacques _eauthor _91173 |
| 700 | 1 | 0 |
_alegoux, Francois _eauthor _91174 |
| 700 | 1 | 0 |
_aLantz, Olivier _eauthor _91175 |
| 245 | 0 | 0 | _aγδ, NKT and MAIT cells during evolution: redundancy or specialized functions? |
| 260 | _c2022-07-15. | ||
| 500 | _a/pmc/articles/PMC7613099/ | ||
| 500 | _a/pubmed/35821101 | ||
| 520 | _aInnate-like T cells display characteristics of both innate lymphoid cells (ILC) and mainstream αβ T cells leading to overlapping functions of innate-like T cells with both subsets. In this review, we show that, while innate-like T cells are probably present in all vertebrates, their main characteristics are much better known in amphibians and mammals. Innate-like T cells encompass both γδ and αβ T cells. In mammals, γδ TCRs likely co-evolved with molecules of the butyrophillin family they interact with, while the semi-invariant TCRs of iNKT and MAIT cells are evolutionarily locked with their restricting MH1b molecules, CD1d and MR1, respectively. The strong conservation of the antigen recognition systems of innate-like T cell subsets despite similar effector potentialities supports that each-one fulfills non-redundant roles related to their antigen specificity. | ||
| 540 | _a | ||
| 546 | _aen | ||
| 690 | _aArticle | ||
| 655 | 7 |
_aText _2local |
|
| 786 | 0 | _nJ Immunol | |
| 856 | 4 | 1 |
_uhttp://dx.doi.org/10.4049/jimmunol.2200105 _zConnect to this object online. |
| 999 |
_c285 _d285 |
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