| 000 | 02539 am a22004093u 4500 | ||
|---|---|---|---|
| 042 | _adc | ||
| 100 | 1 | 0 |
_aChen, Yiheng _eauthor _92921 |
| 700 | 1 | 0 |
_aLu, Tianyuan _eauthor _92922 |
| 700 | 1 | 0 |
_aPettersson-Kymmer, Ulrika _eauthor _92923 |
| 700 | 1 | 0 |
_aStewart, Isobel D. _eauthor _92924 |
| 700 | 1 | 0 |
_aButler-Laporte, Guillaume _eauthor _92925 |
| 700 | 1 | 0 |
_aNakanishi, Tomoko _eauthor _92926 |
| 700 | 1 | 0 |
_aCerani, Agustin _eauthor _92927 |
| 700 | 1 | 0 |
_aLiang, Kevin Y.H. _eauthor _92928 |
| 700 | 1 | 0 |
_aYoshiji, Satoshi _eauthor _92929 |
| 700 | 1 | 0 |
_aWillett, Julian Daniel Sunday _eauthor _92930 |
| 700 | 1 | 0 |
_aSu, Chen-Yang _eauthor _92931 |
| 700 | 1 | 0 |
_aRaina, Parminder _eauthor _92932 |
| 700 | 1 | 0 |
_aGreenwood, Celia M.T. _eauthor _92933 |
| 700 | 1 | 0 |
_aFarjoun, Yossi _eauthor _92934 |
| 700 | 1 | 0 |
_aForgetta, Vincenzo _eauthor _92935 |
| 700 | 1 | 0 |
_aLangenberg, Claudia _eauthor _92936 |
| 700 | 1 | 0 |
_aZhou, Sirui _eauthor _92937 |
| 700 | 1 | 0 |
_aOhlsson, Claes _eauthor _92938 |
| 700 | 1 | 0 |
_aRichards, J Brent _eauthor _92939 |
| 245 | 0 | 0 | _aGenomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases |
| 260 | _c2023-01-01. | ||
| 500 | _a/pmc/articles/PMC7614162/ | ||
| 500 | _a/pubmed/36635386 | ||
| 520 | _aMetabolic processes can influence disease risk and provide therapeutic targets. By conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite ratios, we identified associations with 690 metabolites at 248 loci; and associations with 143 metabolite ratios at 69 loci. Integrating metabolite-gene and gene expression information identified 94 effector genes for 109 metabolites and 48 metabolite ratios. Using Mendelian Randomization (MR), we identified 22 metabolites and 20 metabolite ratios having estimated causal effect on 12 traits and diseases, including orotate for estimated bone mineral density, alpha-hydroxyisovalerate for body mass index and ergothioneine for inflammatory bowel disease and asthma. We further measured orotate level in a separate cohort and demonstrated that, consistent with MR, orotate levels were positively associated with incident hip fractures. This study provides a valuable resource describing the genetic architecture of metabolites and delivers insights into their roles in common diseases, thereby offering opportunities for therapeutic targets. | ||
| 540 | _a | ||
| 546 | _aen | ||
| 690 | _aArticle | ||
| 655 | 7 |
_aText _2local |
|
| 786 | 0 | _nNat Genet | |
| 856 | 4 | 1 |
_uhttp://dx.doi.org/10.1038/s41588-022-01270-1 _zConnect to this object online. |
| 999 |
_c2292 _d2292 |
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