| 000 | 03497 am a22006733u 4500 | ||
|---|---|---|---|
| 042 | _adc | ||
| 100 | 1 | 0 |
_aGur, Chamutal _eauthor _91055 |
| 700 | 1 | 0 |
_aWang, Shuang-Yin _eauthor _91056 |
| 700 | 1 | 0 |
_aSheban, Fadi _eauthor _91057 |
| 700 | 1 | 0 |
_aZada, Mor _eauthor _91058 |
| 700 | 1 | 0 |
_aLi, Baoguo _eauthor _91059 |
| 700 | 1 | 0 |
_aKharouf, Fadi _eauthor _91060 |
| 700 | 1 | 0 |
_aPeleg, Hagit _eauthor _91061 |
| 700 | 1 | 0 |
_aAamar, Suhail _eauthor _91062 |
| 700 | 1 | 0 |
_aYalin, Adam _eauthor _91063 |
| 700 | 1 | 0 |
_aKirschenbaum, Daniel _eauthor _91064 |
| 700 | 1 | 0 |
_aBraun-Moscovici, Yolanda _eauthor _91065 |
| 700 | 1 | 0 |
_aJaitin, Diego Adhemar _eauthor _91066 |
| 700 | 1 | 0 |
_ameir-salame, Tomer _eauthor _91067 |
| 700 | 1 | 0 |
_aHagai, Efrat _eauthor _91068 |
| 700 | 1 | 0 |
_aKragesteen, Bjørt K. _eauthor _91069 |
| 700 | 1 | 0 |
_aAvni, Batia _eauthor _91070 |
| 700 | 1 | 0 |
_aGrisariu, Sigal _eauthor _91071 |
| 700 | 1 | 0 |
_aBornstein, Chamutal _eauthor _91072 |
| 700 | 1 | 0 |
_aShlomi-Loubaton, Shir _eauthor _91073 |
| 700 | 1 | 0 |
_aDavid, Eyal _eauthor _91074 |
| 700 | 1 | 0 |
_aShreberk-Hassidim, Rony _eauthor _91075 |
| 700 | 1 | 0 |
_aMolho-Pessach, Vered _eauthor _91076 |
| 700 | 1 | 0 |
_aAmar, Dalit _eauthor _91077 |
| 700 | 1 | 0 |
_aTzur, Tomer _eauthor _91078 |
| 700 | 1 | 0 |
_aKuint, Rottem _eauthor _91079 |
| 700 | 1 | 0 |
_aGross, Moshe _eauthor _91080 |
| 700 | 1 | 0 |
_aBarboy, Oren _eauthor _91081 |
| 700 | 1 | 0 |
_aMoshe, Adi _eauthor _91082 |
| 700 | 1 | 0 |
_aFellus-Alyagor, Liat _eauthor _91083 |
| 700 | 1 | 0 |
_aHirsch, Dana _eauthor _91084 |
| 700 | 1 | 0 |
_aAddadi, Yoseph _eauthor _91085 |
| 700 | 1 | 0 |
_aErenfeld, Shlomit _eauthor _91086 |
| 700 | 1 | 0 |
_aBiton, Moshe _eauthor _91087 |
| 700 | 1 | 0 |
_aTzemach, Tehila _eauthor _91088 |
| 700 | 1 | 0 |
_aElazary, Anat _eauthor _91089 |
| 700 | 1 | 0 |
_aNaparstek, Yaakov _eauthor _91090 |
| 700 | 1 | 0 |
_aTzemach, Reut _eauthor _91091 |
| 700 | 1 | 0 |
_aWeiner, Assaf _eauthor _91092 |
| 700 | 1 | 0 |
_aGiladi, Amir _eauthor _91093 |
| 700 | 1 | 0 |
_aBalbir-Gurman, Alexandra _eauthor _91094 |
| 700 | 1 | 0 |
_aAmit, Ido _eauthor _91095 |
| 245 | 0 | 0 | _aLGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma |
| 260 | _c2022-04-14. | ||
| 500 | _a/pmc/articles/PMC7612792/ | ||
| 500 | _a/pubmed/35381199 | ||
| 520 | _aSystemic sclerosis (scleroderma, SSc) is an incurable autoimmune disease with high morbidity and mortality rates. Here, we conducted a population-scale single-cell genomic analysis of skin and blood samples of 56 healthy controls and 97 SSc patients at different stages of the disease. We found immune compartment dysfunction only in a specific subtype of diffuse SSc patients but global dysregulation of the stromal compartment, particularly in a previously undefined subset of LGR5(+)-scleroderma-associated fibroblasts (ScAFs). ScAFs are perturbed morphologically and molecularly in SSc patients. Single-cell multiome profiling of stromal cells revealed ScAF-specific markers, pathways, regulatory elements, and transcription factors underlining disease development. Systematic analysis of these molecular features with clinical metadata associates specific ScAF targets with disease pathogenesis and SSc clinical traits. Our high-resolution atlas of the sclerodermatous skin spectrum will enable a paradigm shift in the understanding of SSc disease and facilitate the development of biomarkers and therapeutic strategies. | ||
| 540 | _a | ||
| 546 | _aen | ||
| 690 | _aArticle | ||
| 655 | 7 |
_aText _2local |
|
| 786 | 0 | _nCell | |
| 856 | 4 | 1 |
_uhttp://dx.doi.org/10.1016/j.cell.2022.03.011 _zConnect to this object online. |
| 999 |
_c1830 _d1830 |
||