TY  - BOOK
AU  - De Picker,Livia J.
AU  - Leboyer,Marion
AU  - Geddes,John R.
AU  - Morrens,Manuel
AU  - Harrison,Paul J.
AU  - Taquet,Maxime
TI  - Association between serum lithium level and incidence of COVID-19 infection
PY  - 2022///-07-01
KW  - Text
KW  - local
N1  - /pmc/articles/PMC7612897; /pubmed/35318909
N2  - An antiviral effect of lithium has been proposed, but never investigated for COVID-19. Using electronic health records of 26,554 patients with documented serum lithium levels during the pandemic, we show that the 6-month COVID-19 infection incidence was lower among matched patients with 'therapeutic' (0.50-1.00) vs. 'sub-therapeutic' (0.05-0.50) lithium levels (HR 0.82, 95% CI 0.69-0.97, p=0.017) and among patients with 'therapeutic' lithium levels vs. matched patients using valproate (HR 0.79, 95% CI 0.67-0.92, p=0.0023). Lower rates of infection were observed for both new COVID-19 diagnoses and positive PCR tests, regardless of underlying psychiatric diagnosis and vaccination status
UR  - http://dx.doi.org/10.1192/bjp.2022.42
ER  -