TY  - BOOK
AU  - Lavie,Dor
AU  - Ben-Shmuel,Aviad
AU  - Erez,Neta
AU  - Scherz-Shouval,Ruth
TI  - Cancer-associated fibroblasts in the single-cell era
PY  - 2022///-07
KW  - Text
KW  - local
N1  - /pmc/articles/PMC7613625; /pubmed/35883004
N2  - Cancer-associated fibroblasts (CAFs) are central players in the microenvironment of solid tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes, origins and functions, and consist of distinct subpopulations. Recent progress in single-cell RNA-sequencing technologies has enabled detailed characterization of the complexity and heterogeneity of CAF subpopulations in multiple tumor types. In this Review, we discuss the current understanding of CAF subsets and functions as elucidated by single-cell technologies, their functional plasticity, and their emergent shared and organ-specific features that could potentially be harnessed to design better therapeutic strategies for cancer
UR  - http://dx.doi.org/10.1038/s43018-022-00411-z
ER  -