TY  - BOOK
AU  - Harly,Christelle
AU  - Robert,Jacques
AU  - legoux,Francois
AU  - Lantz,Olivier
TI  - γδ, NKT and MAIT cells during evolution: redundancy or specialized functions?
PY  - 2022///-07-15
KW  - Text
KW  - local
N1  - /pmc/articles/PMC7613099; /pubmed/35821101
N2  - Innate-like T cells display characteristics of both innate lymphoid cells (ILC) and mainstream αβ T cells leading to overlapping functions of innate-like T cells with both subsets. In this review, we show that, while innate-like T cells are probably present in all vertebrates, their main characteristics are much better known in amphibians and mammals. Innate-like T cells encompass both γδ and αβ T cells. In mammals, γδ TCRs likely co-evolved with molecules of the butyrophillin family they interact with, while the semi-invariant TCRs of iNKT and MAIT cells are evolutionarily locked with their restricting MH1b molecules, CD1d and MR1, respectively. The strong conservation of the antigen recognition systems of innate-like T cell subsets despite similar effector potentialities supports that each-one fulfills non-redundant roles related to their antigen specificity
UR  - http://dx.doi.org/10.4049/jimmunol.2200105
ER  -