Harly, Christelle <br/><br/>
γδ, NKT and MAIT cells during evolution: redundancy or specialized functions? 

 -  2022-07-15. 
<br/><br/> /pmc/articles/PMC7613099/  /pubmed/35821101 
<br/><br/> Innate-like T cells display characteristics of both innate lymphoid cells (ILC) and mainstream αβ T cells leading to overlapping functions of innate-like T cells with both subsets. In this review, we show that, while innate-like T cells are probably present in all vertebrates, their main characteristics are much better known in amphibians and mammals. Innate-like T cells encompass both γδ and αβ T cells. In mammals, γδ TCRs likely co-evolved with molecules of the butyrophillin family they interact with, while the semi-invariant TCRs of iNKT and MAIT cells are evolutionarily locked with their restricting MH1b molecules, CD1d and MR1, respectively. The strong conservation of the antigen recognition systems of innate-like T cell subsets despite similar effector potentialities supports that each-one fulfills non-redundant roles related to their antigen specificity. 
<br/><br/><br/> 
<br/><br/><br/>en 
<br/><br/><label>Index Terms--Genre/Form: </label><br/>Text