JOM KITA KE POLITEKNIK
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γδ, NKT and MAIT cells during evolution: redundancy or specialized functions?

By: Contributor(s): Publication details: 2022-07-15.Subject(s): Genre/Form: Online resources: Summary: Innate-like T cells display characteristics of both innate lymphoid cells (ILC) and mainstream αβ T cells leading to overlapping functions of innate-like T cells with both subsets. In this review, we show that, while innate-like T cells are probably present in all vertebrates, their main characteristics are much better known in amphibians and mammals. Innate-like T cells encompass both γδ and αβ T cells. In mammals, γδ TCRs likely co-evolved with molecules of the butyrophillin family they interact with, while the semi-invariant TCRs of iNKT and MAIT cells are evolutionarily locked with their restricting MH1b molecules, CD1d and MR1, respectively. The strong conservation of the antigen recognition systems of innate-like T cell subsets despite similar effector potentialities supports that each-one fulfills non-redundant roles related to their antigen specificity.
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/pmc/articles/PMC7613099/

/pubmed/35821101

Innate-like T cells display characteristics of both innate lymphoid cells (ILC) and mainstream αβ T cells leading to overlapping functions of innate-like T cells with both subsets. In this review, we show that, while innate-like T cells are probably present in all vertebrates, their main characteristics are much better known in amphibians and mammals. Innate-like T cells encompass both γδ and αβ T cells. In mammals, γδ TCRs likely co-evolved with molecules of the butyrophillin family they interact with, while the semi-invariant TCRs of iNKT and MAIT cells are evolutionarily locked with their restricting MH1b molecules, CD1d and MR1, respectively. The strong conservation of the antigen recognition systems of innate-like T cell subsets despite similar effector potentialities supports that each-one fulfills non-redundant roles related to their antigen specificity.

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