JOM KITA KE POLITEKNIK

Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases (Record no. 975)

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Personal name Chen, Yiheng
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9 (RLIN) 2921
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Title Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases
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Date of publication, distribution, etc. 2023-01-01.
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General note /pmc/articles/PMC7614162/
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General note /pubmed/36635386
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Summary, etc. Metabolic processes can influence disease risk and provide therapeutic targets. By conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite ratios, we identified associations with 690 metabolites at 248 loci; and associations with 143 metabolite ratios at 69 loci. Integrating metabolite-gene and gene expression information identified 94 effector genes for 109 metabolites and 48 metabolite ratios. Using Mendelian Randomization (MR), we identified 22 metabolites and 20 metabolite ratios having estimated causal effect on 12 traits and diseases, including orotate for estimated bone mineral density, alpha-hydroxyisovalerate for body mass index and ergothioneine for inflammatory bowel disease and asthma. We further measured orotate level in a separate cohort and demonstrated that, consistent with MR, orotate levels were positively associated with incident hip fractures. This study provides a valuable resource describing the genetic architecture of metabolites and delivers insights into their roles in common diseases, thereby offering opportunities for therapeutic targets.
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Language note en
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Personal name Lu, Tianyuan
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9 (RLIN) 2922
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Personal name Pettersson-Kymmer, Ulrika
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9 (RLIN) 2923
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Personal name Stewart, Isobel D.
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9 (RLIN) 2924
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Personal name Butler-Laporte, Guillaume
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9 (RLIN) 2925
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Personal name Nakanishi, Tomoko
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9 (RLIN) 2926
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Personal name Cerani, Agustin
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9 (RLIN) 2927
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Personal name Liang, Kevin Y.H.
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9 (RLIN) 2928
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Personal name Yoshiji, Satoshi
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9 (RLIN) 2929
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Personal name Willett, Julian Daniel Sunday
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Personal name Su, Chen-Yang
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9 (RLIN) 2931
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Personal name Raina, Parminder
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9 (RLIN) 2932
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Personal name Greenwood, Celia M.T.
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9 (RLIN) 2933
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Personal name Farjoun, Yossi
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9 (RLIN) 2934
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Personal name Forgetta, Vincenzo
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9 (RLIN) 2935
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Personal name Langenberg, Claudia
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Personal name Zhou, Sirui
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9 (RLIN) 2937
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Personal name Ohlsson, Claes
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9 (RLIN) 2938
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Personal name Richards, J Brent
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9 (RLIN) 2939
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Note Nat Genet
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1038/s41588-022-01270-1">http://dx.doi.org/10.1038/s41588-022-01270-1</a>
Public note Connect to this object online.

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