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Rhoptry secretion system structure and priming in Plasmodium falciparum revealed using in situ cryo-electron tomography (Record no. 784)

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Personal name Martinez, Matthew
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9 (RLIN) 1245
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Title Rhoptry secretion system structure and priming in Plasmodium falciparum revealed using in situ cryo-electron tomography
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Date of publication, distribution, etc. 2022-07-11.
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General note /pmc/articles/PMC7613239/
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General note /pubmed/35817892
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Summary, etc. Apicomplexan parasites secrete contents of the rhoptries, club-shaped organelles in the apical region, into host cells to permit their invasion and establishment of infection. The rhoptry secretory apparatus (RSA), which is critical for rhoptry secretion, was recently discovered in Toxoplasma and Cryptosporidium. It is unknown if a similar molecular machinery exists in the malaria parasite Plasmodium. In this study, we use in situ cryo-electron tomography to investigate the rhoptry secretion system in P. falciparum merozoites. We identify the presence of an RSA at the cell apex and a morphologically distinct apical vesicle docking the tips of the two rhoptries to the RSA. We also discover two additional rhoptry organizations that lack the apical vesicle. Using subtomogram averaging, we reveal different conformations of the RSA structure corresponding to different rhoptry organizations. Our results highlight previously unknown steps in the process of rhoptry secretion and indicate a regulatory role for the conserved apical vesicle in host invasion by apicomplexan parasites.
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Terms governing use and reproduction
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Terms governing use and reproduction https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Chen, William David
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9 (RLIN) 1246
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Personal name Cova, Marta Mendonça
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9 (RLIN) 1247
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Personal name Molnár, Petra
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9 (RLIN) 1248
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Personal name Mageswaran, Shrawan Kumar
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9 (RLIN) 1249
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Personal name Guérin, Amandine
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9 (RLIN) 1250
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Personal name John, Audrey R. Odom
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9 (RLIN) 1251
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Personal name Lebrun, Maryse
Relator term author
9 (RLIN) 1252
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Personal name Chang, Yi-Wei
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9 (RLIN) 1253
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Note Nat Microbiol
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1038/s41564-022-01171-3">http://dx.doi.org/10.1038/s41564-022-01171-3</a>
Public note Connect to this object online.

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