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γδ, NKT and MAIT cells during evolution: redundancy or specialized functions? (Record no. 776)

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Personal name Harly, Christelle
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9 (RLIN) 1172
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Title γδ, NKT and MAIT cells during evolution: redundancy or specialized functions?
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Date of publication, distribution, etc. 2022-07-15.
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General note /pmc/articles/PMC7613099/
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General note /pubmed/35821101
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Summary, etc. Innate-like T cells display characteristics of both innate lymphoid cells (ILC) and mainstream αβ T cells leading to overlapping functions of innate-like T cells with both subsets. In this review, we show that, while innate-like T cells are probably present in all vertebrates, their main characteristics are much better known in amphibians and mammals. Innate-like T cells encompass both γδ and αβ T cells. In mammals, γδ TCRs likely co-evolved with molecules of the butyrophillin family they interact with, while the semi-invariant TCRs of iNKT and MAIT cells are evolutionarily locked with their restricting MH1b molecules, CD1d and MR1, respectively. The strong conservation of the antigen recognition systems of innate-like T cell subsets despite similar effector potentialities supports that each-one fulfills non-redundant roles related to their antigen specificity.
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Terms governing use and reproduction
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Language note en
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Topical term or geographic name as entry element Article
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Personal name Robert, Jacques
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9 (RLIN) 1173
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Personal name legoux, Francois
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9 (RLIN) 1174
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Personal name Lantz, Olivier
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9 (RLIN) 1175
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Note J Immunol
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Uniform Resource Identifier <a href="http://dx.doi.org/10.4049/jimmunol.2200105">http://dx.doi.org/10.4049/jimmunol.2200105</a>
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