JOM KITA KE POLITEKNIK

Renal engineering: strategies to address the problem of the ureter (Record no. 397)

MARC details
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Authentication code dc
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Personal name Davies, Jamie A.
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9 (RLIN) 2235
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Title Renal engineering: strategies to address the problem of the ureter
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Date of publication, distribution, etc. 2021-12.
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General note /pmc/articles/PMC7614056/
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General note /pubmed/36644495
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Summary, etc. Current techniques for making renal organoids generate tissues that show function when transplanted into a host, but they have no ureter through which urine can drain. There are at least 4 possible strategies for adding a ureter: connecting to ta host ureter; inducing an engineered kidney to make a ureter; making a stem-cell derived ureter; and replacement of only damaged cortex and outer medulla, using remaining host calyces, pelvis and ureter. Here we review progress: local BMP4 can induce a collecting duct tubule to become a ureter; a urothelial tube can be produced directly from pluripotent cells, and connect to the collecting duct system of a renal organoid; it is possible to graft ES cell-derived ureters into host kidney rudiments and see connection, smooth muscle development and spontaneous contraction, but this has not yet been achieved with all components being derived from ES cells. Remaining problems are discussed.
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Terms governing use and reproduction
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Elhendawi, Mona
Relator term author
9 (RLIN) 2236
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Personal name Palakkan, Anwar A.
Relator term author
9 (RLIN) 2237
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Personal name Sallam, May
Relator term author
9 (RLIN) 2238
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Note Curr Opin Biomed Eng
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1016/j.cobme.2021.100334">http://dx.doi.org/10.1016/j.cobme.2021.100334</a>
Public note Connect to this object online.
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from
    Dewey Decimal Classification     English Beaconhouse Newlands Beaconhouse Newlands 29/01/2024   800.42 bk1000000000 29/01/2024 29/01/2024