JOM KITA KE POLITEKNIK

GnRH replacement rescues cognition in Down Syndrome (Record no. 324)

MARC details
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Personal name Manfredi-Lozano, Maria
Relator term author
9 (RLIN) 1529
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Title GnRH replacement rescues cognition in Down Syndrome
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2022-09-02.
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General note /pmc/articles/PMC7613827/
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General note /pubmed/36048943
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Summary, etc. Currently, no viable treatment exists for cognitive and olfactory deficits in Down syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive non-reproductive neurological symptoms closely parallel a post-pubertal decrease in hypothalamic as well as extra-hypothalamic expression of a master molecule controlling reproduction - gonadotropin-releasing hormone (GnRH), and appear related to an imbalance in a microRNA-gene network known to regulate GnRH neuron maturation together with altered hippocampal synaptic transmission. Epigenetic, cellular, chemogenetic and pharmacological interventions that restore physiological GnRH levels abolish olfactory and cognitive defects in Ts65Dn mice, while pulsatile GnRH therapy improves cognition and brain connectivity in adult DS patients. GnRH thus plays a crucial role in olfaction and cognition, and pulsatile GnRH therapy holds promise to improve cognitive deficits in DS.
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Terms governing use and reproduction
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Leysen, Valerie
Relator term author
9 (RLIN) 1530
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Adamo, Michela
Relator term author
9 (RLIN) 1531
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Personal name Paiva, Isabel
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9 (RLIN) 1532
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Personal name Rovera, Renaud
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9 (RLIN) 1533
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Personal name Pignat, Jean-Michel
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9 (RLIN) 1534
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Personal name Timzoura, Fatima Ezzahra
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9 (RLIN) 1535
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Candlish, Michael
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9 (RLIN) 1536
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Personal name Eddarkaoui, Sabiha
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9 (RLIN) 1537
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Personal name Malone, Samuel A.
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9 (RLIN) 1538
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Personal name Silva, Mauro S. B.
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9 (RLIN) 1539
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Personal name Trova, Sara
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9 (RLIN) 1540
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Personal name Imbernon, Monica
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9 (RLIN) 1541
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Decoster, Laurine
Relator term author
9 (RLIN) 1542
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Cotellessa, Ludovica
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9 (RLIN) 1543
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Personal name Tena-Sempere, Manuel
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9 (RLIN) 1544
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Personal name Claret, Marc
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9 (RLIN) 1545
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Personal name Paoloni-Giacobino, Ariane
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9 (RLIN) 1546
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Personal name Plassard, Damien
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9 (RLIN) 1547
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Personal name Paccou, Emmanuelle
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9 (RLIN) 1548
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Personal name Vionnet, Nathalie
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9 (RLIN) 1549
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Personal name Acierno, James
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9 (RLIN) 1550
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Personal name Maceski, Aleksandra Maleska
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9 (RLIN) 1551
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Personal name Lutti, Antoine
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Personal name Pfrieger, Frank
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9 (RLIN) 1553
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Personal name Rasika, S.
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9 (RLIN) 1554
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Personal name Santoni, Federico
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9 (RLIN) 1555
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Personal name Boehm, Ulrich
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9 (RLIN) 1556
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Personal name Ciofi, Philippe
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9 (RLIN) 1557
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Personal name Buée, Luc
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9 (RLIN) 1558
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Personal name Haddjeri, Nasser
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9 (RLIN) 1559
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Personal name Boutillier, Anne-Laurence
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9 (RLIN) 1560
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Personal name Kuhle, Jens
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9 (RLIN) 1561
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Personal name Messina, Andrea
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9 (RLIN) 1562
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Personal name Draganski, Bogdan
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9 (RLIN) 1563
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Personal name Giacobini, Paolo
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9 (RLIN) 1564
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Personal name Pitteloud, Nelly
Relator term author
9 (RLIN) 1565
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Personal name Prevot, Vincent
Relator term author
9 (RLIN) 1566
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Note Science
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1126/science.abq4515">http://dx.doi.org/10.1126/science.abq4515</a>
Public note Connect to this object online.

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