LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma (Record no. 278)
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042 ## - AUTHENTICATION CODE | |
---|---|
Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Gur, Chamutal |
Relator term | author |
9 (RLIN) | 1055 |
245 00 - TITLE STATEMENT | |
Title | LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2022-04-14. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7612792/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/35381199 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Systemic sclerosis (scleroderma, SSc) is an incurable autoimmune disease with high morbidity and mortality rates. Here, we conducted a population-scale single-cell genomic analysis of skin and blood samples of 56 healthy controls and 97 SSc patients at different stages of the disease. We found immune compartment dysfunction only in a specific subtype of diffuse SSc patients but global dysregulation of the stromal compartment, particularly in a previously undefined subset of LGR5(+)-scleroderma-associated fibroblasts (ScAFs). ScAFs are perturbed morphologically and molecularly in SSc patients. Single-cell multiome profiling of stromal cells revealed ScAF-specific markers, pathways, regulatory elements, and transcription factors underlining disease development. Systematic analysis of these molecular features with clinical metadata associates specific ScAF targets with disease pathogenesis and SSc clinical traits. Our high-resolution atlas of the sclerodermatous skin spectrum will enable a paradigm shift in the understanding of SSc disease and facilitate the development of biomarkers and therapeutic strategies. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Wang, Shuang-Yin |
Relator term | author |
9 (RLIN) | 1056 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Sheban, Fadi |
Relator term | author |
9 (RLIN) | 1057 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Zada, Mor |
Relator term | author |
9 (RLIN) | 1058 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Li, Baoguo |
Relator term | author |
9 (RLIN) | 1059 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kharouf, Fadi |
Relator term | author |
9 (RLIN) | 1060 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Peleg, Hagit |
Relator term | author |
9 (RLIN) | 1061 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Aamar, Suhail |
Relator term | author |
9 (RLIN) | 1062 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Yalin, Adam |
Relator term | author |
9 (RLIN) | 1063 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kirschenbaum, Daniel |
Relator term | author |
9 (RLIN) | 1064 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Braun-Moscovici, Yolanda |
Relator term | author |
9 (RLIN) | 1065 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Jaitin, Diego Adhemar |
Relator term | author |
9 (RLIN) | 1066 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | meir-salame, Tomer |
Relator term | author |
9 (RLIN) | 1067 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Hagai, Efrat |
Relator term | author |
9 (RLIN) | 1068 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kragesteen, Bjørt K. |
Relator term | author |
9 (RLIN) | 1069 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Avni, Batia |
Relator term | author |
9 (RLIN) | 1070 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Grisariu, Sigal |
Relator term | author |
9 (RLIN) | 1071 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Bornstein, Chamutal |
Relator term | author |
9 (RLIN) | 1072 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Shlomi-Loubaton, Shir |
Relator term | author |
9 (RLIN) | 1073 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | David, Eyal |
Relator term | author |
9 (RLIN) | 1074 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Shreberk-Hassidim, Rony |
Relator term | author |
9 (RLIN) | 1075 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Molho-Pessach, Vered |
Relator term | author |
9 (RLIN) | 1076 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Amar, Dalit |
Relator term | author |
9 (RLIN) | 1077 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Tzur, Tomer |
Relator term | author |
9 (RLIN) | 1078 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kuint, Rottem |
Relator term | author |
9 (RLIN) | 1079 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Gross, Moshe |
Relator term | author |
9 (RLIN) | 1080 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Barboy, Oren |
Relator term | author |
9 (RLIN) | 1081 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Moshe, Adi |
Relator term | author |
9 (RLIN) | 1082 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Fellus-Alyagor, Liat |
Relator term | author |
9 (RLIN) | 1083 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Hirsch, Dana |
Relator term | author |
9 (RLIN) | 1084 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Addadi, Yoseph |
Relator term | author |
9 (RLIN) | 1085 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Erenfeld, Shlomit |
Relator term | author |
9 (RLIN) | 1086 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Biton, Moshe |
Relator term | author |
9 (RLIN) | 1087 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Tzemach, Tehila |
Relator term | author |
9 (RLIN) | 1088 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Elazary, Anat |
Relator term | author |
9 (RLIN) | 1089 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Naparstek, Yaakov |
Relator term | author |
9 (RLIN) | 1090 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Tzemach, Reut |
Relator term | author |
9 (RLIN) | 1091 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Weiner, Assaf |
Relator term | author |
9 (RLIN) | 1092 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Giladi, Amir |
Relator term | author |
9 (RLIN) | 1093 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Balbir-Gurman, Alexandra |
Relator term | author |
9 (RLIN) | 1094 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Amit, Ido |
Relator term | author |
9 (RLIN) | 1095 |
786 0# - DATA SOURCE ENTRY | |
Note | Cell |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1016/j.cell.2022.03.011">http://dx.doi.org/10.1016/j.cell.2022.03.011</a> |
Public note | Connect to this object online. |
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