Renal Function and Coronary Bypass Surgery in Patients With Ischemic Heart Failure (Record no. 262)
[ view plain ]
042 ## - AUTHENTICATION CODE | |
---|---|
Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Doenst, Torsten |
Relator term | author |
9 (RLIN) | 965 |
245 00 - TITLE STATEMENT | |
Title | Renal Function and Coronary Bypass Surgery in Patients With Ischemic Heart Failure |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2022-02. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7541611/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/32386761 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | OBJECTIVE: Chronic kidney disease (CKD) is a known risk factor in cardiovascular (CV) disease but its influence on treatment effect of bypass surgery (CABG) remains unclear. We assessed the influence of CKD on 10-year mortality and CV-outcomes in ischemic HF patients treated with medical therapy (MED) with or without CABG. METHODS: We calculated baseline estimated glomerular filtration rate (eGFR, CKD-EPI formula, CKD stages 1-5) from 1,209 patients randomized to MED or CABG in the Surgical Treatment for IsChemic Heart failure (STICH) trial and assessed its effect on outcome. RESULTS: In the overall STICH cohort, patients in CKD stages 3-5 were older than those in stages 1/2 (66-71 vs. 54-59 years) and had more comorbidities. Multivariable modeling revealed an inverse association between eGFR and risk of death, CV death and/or CV-rehospitalization (all p<0.001, but not for stroke, p=0.697). Baseline characteristics of the two treatment arms were equal for each CKD stage. There were significant improvements in death or CV-rehospitalization with CABG (Stage 1: HR 0.71, CI 0.53-0.96, p=0.02; Stage 2: HR 0.71, CI 0.59-0.84, p<0.0001; Stage 3: HR 0.76, CI 0.53-0.96, p=0.03). These data were inconclusive in stages 4/5 for insufficient patient numbers (N=28). There was no significant interaction of eGFR with the treatment effect of CABG (p=0.25 for death and 0.54 for death or CV-rehospitalization). CONCLUSIONS: Chronic kidney disease is an independent risk factor for mortality in patients with ischemic HF with or without CABG. However, mild to moderate CKD does not appear to influence long-term treatment effects of CABG. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Haddad, Haissam |
Relator term | author |
9 (RLIN) | 966 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Stebbins, Amanda |
Relator term | author |
9 (RLIN) | 967 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Hill, James A. |
Relator term | author |
9 (RLIN) | 968 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Velazquez, Eric J. |
Relator term | author |
9 (RLIN) | 969 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Lee, Kerry L. |
Relator term | author |
9 (RLIN) | 970 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Rouleau, Jean L. |
Relator term | author |
9 (RLIN) | 971 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Sopko, George |
Relator term | author |
9 (RLIN) | 972 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Farsky, Pedro S. |
Relator term | author |
9 (RLIN) | 973 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Al-Khalidi, Hussein R. |
Relator term | author |
9 (RLIN) | 974 |
786 0# - DATA SOURCE ENTRY | |
Note | J Thorac Cardiovasc Surg |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1016/j.jtcvs.2020.02.136">http://dx.doi.org/10.1016/j.jtcvs.2020.02.136</a> |
Public note | Connect to this object online. |
No items available.