JOM KITA KE POLITEKNIK

The Development and Internal Evaluation of a Predictive Model to Identify for Whom Mindfulness-Based Cognitive Therapy Offers Superior Relapse Prevention for Recurrent Depression Versus Maintenance Antidepressant Medication (Record no. 2294)

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Personal name Cohen, Zachary D.
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9 (RLIN) 2496
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Title The Development and Internal Evaluation of a Predictive Model to Identify for Whom Mindfulness-Based Cognitive Therapy Offers Superior Relapse Prevention for Recurrent Depression Versus Maintenance Antidepressant Medication
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Name of publisher, distributor, etc. SAGE Publications,
Date of publication, distribution, etc. 2022-04-29.
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General note /pmc/articles/PMC7614103/
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General note /pubmed/36698442
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Summary, etc. Depression is highly recurrent, even following successful pharmacological and/or psychological intervention. We aimed to develop clinical prediction models to inform adults with recurrent depression choosing between antidepressant medication (ADM) maintenance or switching to mindfulness-based cognitive therapy (MBCT). Using previously published data (N = 424), we constructed prognostic models using elastic-net regression that combined demographic, clinical, and psychological factors to predict relapse at 24 months under ADM or MBCT. Only the ADM model (discrimination performance: area under the curve [AUC] = .68) predicted relapse better than baseline depression severity (AUC = .54; one-tailed DeLong's test: z = 2.8, p = .003). Individuals with the poorest ADM prognoses who switched to MBCT had better outcomes compared with individuals who maintained ADM (48% vs. 70% relapse, respectively; superior survival times, z = −2.7, p = .008). For individuals with moderate to good ADM prognoses, both treatments resulted in similar likelihood of relapse. If replicated, the results suggest that predictive modeling can inform clinical decision-making around relapse prevention in recurrent depression.
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Terms governing use and reproduction © The Author(s) 2022
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Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
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Language note en
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Topical term or geographic name as entry element Empirical Articles
9 (RLIN) 2505
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Genre/form data or focus term Text
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Personal name DeRubeis, Robert J.
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9 (RLIN) 2497
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Personal name Hayes, Rachel
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9 (RLIN) 2498
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Personal name Watkins, Edward R.
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9 (RLIN) 2499
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Personal name Lewis, Glyn
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9 (RLIN) 2500
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Personal name Byng, Richard
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9 (RLIN) 2501
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Personal name Byford, Sarah
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9 (RLIN) 2502
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Personal name Crane, Catherine
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9 (RLIN) 2503
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Personal name Kuyken, Willem
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9 (RLIN) 2504
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Personal name Dalgleish, Tim
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9 (RLIN) 1970
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Personal name Schweizer, Susanne
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9 (RLIN) 1969
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Note Clin Psychol Sci
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1177/21677026221076832">http://dx.doi.org/10.1177/21677026221076832</a>
Public note Connect to this object online.

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