Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases (Record no. 2292)
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042 ## - AUTHENTICATION CODE | |
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Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Chen, Yiheng |
Relator term | author |
9 (RLIN) | 2921 |
245 00 - TITLE STATEMENT | |
Title | Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2023-01-01. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7614162/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/36635386 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Metabolic processes can influence disease risk and provide therapeutic targets. By conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite ratios, we identified associations with 690 metabolites at 248 loci; and associations with 143 metabolite ratios at 69 loci. Integrating metabolite-gene and gene expression information identified 94 effector genes for 109 metabolites and 48 metabolite ratios. Using Mendelian Randomization (MR), we identified 22 metabolites and 20 metabolite ratios having estimated causal effect on 12 traits and diseases, including orotate for estimated bone mineral density, alpha-hydroxyisovalerate for body mass index and ergothioneine for inflammatory bowel disease and asthma. We further measured orotate level in a separate cohort and demonstrated that, consistent with MR, orotate levels were positively associated with incident hip fractures. This study provides a valuable resource describing the genetic architecture of metabolites and delivers insights into their roles in common diseases, thereby offering opportunities for therapeutic targets. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Lu, Tianyuan |
Relator term | author |
9 (RLIN) | 2922 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Pettersson-Kymmer, Ulrika |
Relator term | author |
9 (RLIN) | 2923 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Stewart, Isobel D. |
Relator term | author |
9 (RLIN) | 2924 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Butler-Laporte, Guillaume |
Relator term | author |
9 (RLIN) | 2925 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Nakanishi, Tomoko |
Relator term | author |
9 (RLIN) | 2926 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Cerani, Agustin |
Relator term | author |
9 (RLIN) | 2927 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Liang, Kevin Y.H. |
Relator term | author |
9 (RLIN) | 2928 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Yoshiji, Satoshi |
Relator term | author |
9 (RLIN) | 2929 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Willett, Julian Daniel Sunday |
Relator term | author |
9 (RLIN) | 2930 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Su, Chen-Yang |
Relator term | author |
9 (RLIN) | 2931 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Raina, Parminder |
Relator term | author |
9 (RLIN) | 2932 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Greenwood, Celia M.T. |
Relator term | author |
9 (RLIN) | 2933 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Farjoun, Yossi |
Relator term | author |
9 (RLIN) | 2934 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Forgetta, Vincenzo |
Relator term | author |
9 (RLIN) | 2935 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Langenberg, Claudia |
Relator term | author |
9 (RLIN) | 2936 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Zhou, Sirui |
Relator term | author |
9 (RLIN) | 2937 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Ohlsson, Claes |
Relator term | author |
9 (RLIN) | 2938 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Richards, J Brent |
Relator term | author |
9 (RLIN) | 2939 |
786 0# - DATA SOURCE ENTRY | |
Note | Nat Genet |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1038/s41588-022-01270-1">http://dx.doi.org/10.1038/s41588-022-01270-1</a> |
Public note | Connect to this object online. |
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