GnRH replacement rescues cognition in Down Syndrome (Record no. 1975)
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042 ## - AUTHENTICATION CODE | |
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Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Manfredi-Lozano, Maria |
Relator term | author |
9 (RLIN) | 1529 |
245 00 - TITLE STATEMENT | |
Title | GnRH replacement rescues cognition in Down Syndrome |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2022-09-02. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7613827/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/36048943 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Currently, no viable treatment exists for cognitive and olfactory deficits in Down syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive non-reproductive neurological symptoms closely parallel a post-pubertal decrease in hypothalamic as well as extra-hypothalamic expression of a master molecule controlling reproduction - gonadotropin-releasing hormone (GnRH), and appear related to an imbalance in a microRNA-gene network known to regulate GnRH neuron maturation together with altered hippocampal synaptic transmission. Epigenetic, cellular, chemogenetic and pharmacological interventions that restore physiological GnRH levels abolish olfactory and cognitive defects in Ts65Dn mice, while pulsatile GnRH therapy improves cognition and brain connectivity in adult DS patients. GnRH thus plays a crucial role in olfaction and cognition, and pulsatile GnRH therapy holds promise to improve cognitive deficits in DS. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Leysen, Valerie |
Relator term | author |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Adamo, Michela |
Relator term | author |
9 (RLIN) | 1531 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Paiva, Isabel |
Relator term | author |
9 (RLIN) | 1532 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Rovera, Renaud |
Relator term | author |
9 (RLIN) | 1533 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Pignat, Jean-Michel |
Relator term | author |
9 (RLIN) | 1534 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Timzoura, Fatima Ezzahra |
Relator term | author |
9 (RLIN) | 1535 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Candlish, Michael |
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9 (RLIN) | 1536 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Eddarkaoui, Sabiha |
Relator term | author |
9 (RLIN) | 1537 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Malone, Samuel A. |
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9 (RLIN) | 1538 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Silva, Mauro S. B. |
Relator term | author |
9 (RLIN) | 1539 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Trova, Sara |
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9 (RLIN) | 1540 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Imbernon, Monica |
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700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Decoster, Laurine |
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9 (RLIN) | 1542 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Cotellessa, Ludovica |
Relator term | author |
9 (RLIN) | 1543 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Tena-Sempere, Manuel |
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700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Claret, Marc |
Relator term | author |
9 (RLIN) | 1545 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Paoloni-Giacobino, Ariane |
Relator term | author |
9 (RLIN) | 1546 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Plassard, Damien |
Relator term | author |
9 (RLIN) | 1547 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Paccou, Emmanuelle |
Relator term | author |
9 (RLIN) | 1548 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Vionnet, Nathalie |
Relator term | author |
9 (RLIN) | 1549 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Acierno, James |
Relator term | author |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Maceski, Aleksandra Maleska |
Relator term | author |
9 (RLIN) | 1551 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Lutti, Antoine |
Relator term | author |
9 (RLIN) | 1552 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Pfrieger, Frank |
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9 (RLIN) | 1553 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Rasika, S. |
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700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Santoni, Federico |
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700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Boehm, Ulrich |
Relator term | author |
9 (RLIN) | 1556 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Ciofi, Philippe |
Relator term | author |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Buée, Luc |
Relator term | author |
9 (RLIN) | 1558 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Haddjeri, Nasser |
Relator term | author |
9 (RLIN) | 1559 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Boutillier, Anne-Laurence |
Relator term | author |
9 (RLIN) | 1560 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kuhle, Jens |
Relator term | author |
9 (RLIN) | 1561 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Messina, Andrea |
Relator term | author |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Draganski, Bogdan |
Relator term | author |
9 (RLIN) | 1563 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Giacobini, Paolo |
Relator term | author |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Pitteloud, Nelly |
Relator term | author |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Prevot, Vincent |
Relator term | author |
786 0# - DATA SOURCE ENTRY | |
Note | Science |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1126/science.abq4515">http://dx.doi.org/10.1126/science.abq4515</a> |
Public note | Connect to this object online. |
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