JOM KITA KE POLITEKNIK

Cancer-associated fibroblasts in the single-cell era (Record no. 1917)

MARC details
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Authentication code dc
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Personal name Lavie, Dor
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9 (RLIN) 1364
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Title Cancer-associated fibroblasts in the single-cell era
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Date of publication, distribution, etc. 2022-07.
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General note /pmc/articles/PMC7613625/
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General note /pubmed/35883004
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Summary, etc. Cancer-associated fibroblasts (CAFs) are central players in the microenvironment of solid tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes, origins and functions, and consist of distinct subpopulations. Recent progress in single-cell RNA-sequencing technologies has enabled detailed characterization of the complexity and heterogeneity of CAF subpopulations in multiple tumor types. In this Review, we discuss the current understanding of CAF subsets and functions as elucidated by single-cell technologies, their functional plasticity, and their emergent shared and organ-specific features that could potentially be harnessed to design better therapeutic strategies for cancer.
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Terms governing use and reproduction
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Terms governing use and reproduction https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
Source of term local
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Personal name Ben-Shmuel, Aviad
Relator term author
9 (RLIN) 1365
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Personal name Erez, Neta
Relator term author
9 (RLIN) 1366
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Personal name Scherz-Shouval, Ruth
Relator term author
9 (RLIN) 1367
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Note Nat Cancer
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1038/s43018-022-00411-z">http://dx.doi.org/10.1038/s43018-022-00411-z</a>
Public note Connect to this object online.

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