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Association between serum lithium level and incidence of COVID-19 infection (Record no. 1835)

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Personal name De Picker, Livia J.
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9 (RLIN) 1097
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Title Association between serum lithium level and incidence of COVID-19 infection
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Date of publication, distribution, etc. 2022-07-01.
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General note /pmc/articles/PMC7612897/
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General note /pubmed/35318909
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Summary, etc. An antiviral effect of lithium has been proposed, but never investigated for COVID-19. Using electronic health records of 26,554 patients with documented serum lithium levels during the pandemic, we show that the 6-month COVID-19 infection incidence was lower among matched patients with 'therapeutic' (0.50-1.00) vs. 'sub-therapeutic' (0.05-0.50) lithium levels (HR 0.82, 95% CI 0.69-0.97, p=0.017) and among patients with 'therapeutic' lithium levels vs. matched patients using valproate (HR 0.79, 95% CI 0.67-0.92, p=0.0023). Lower rates of infection were observed for both new COVID-19 diagnoses and positive PCR tests, regardless of underlying psychiatric diagnosis and vaccination status.
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Language note en
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Topical term or geographic name as entry element Article
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Personal name Leboyer, Marion
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9 (RLIN) 1098
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Personal name Geddes, John R.
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9 (RLIN) 1099
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Personal name Morrens, Manuel
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9 (RLIN) 1100
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Personal name Harrison, Paul J.
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9 (RLIN) 1101
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Personal name Taquet, Maxime
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9 (RLIN) 1102
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Note Br J Psychiatry
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1192/bjp.2022.42">http://dx.doi.org/10.1192/bjp.2022.42</a>
Public note Connect to this object online.

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