JOM KITA KE POLITEKNIK

Viral biogeography of the mammalian gut and parenchymal organs (Record no. 1832)

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Personal name Shkoporov, Andrey N.
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9 (RLIN) 2042
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Title Viral biogeography of the mammalian gut and parenchymal organs
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Date of publication, distribution, etc. 2022-08-01.
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General note /pmc/articles/PMC7614033/
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General note /pubmed/35918425
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Summary, etc. The mammalian virome has been linked to health and disease but our understanding of how it is structured along the longitudinal axis of the mammalian gastrointestinal tract (GIT) and other organs is limited. Here we report a metagenomic analysis of the prokaryotic and eukaryotic virome occupying luminal and mucosa-associated habitats along the GIT, as well as parenchymal organs (liver, lung and spleen), in two representative mammalian species, the domestic pig and rhesus macaque (six animals per species). Luminal samples from the large intestine of both mammals harboured the highest loads and diversity of bacteriophages (class Caudoviricetes, family Microviridae and others). Mucosal samples contained much lower viral loads but a higher proportion of eukaryotic viruses (families Astroviridae, Caliciviridae, Parvoviridae). Parenchymal organs contained significant numbers of bacteriophages of gut origin, in addition to some eukaryotic viruses. Overall, GIT virome composition was specific to anatomical region and host species. Upper GIT and mucosa-specific viruses were greatly under-represented in distal colon samples (a proxy for faeces). Nonetheless, certain viral and phage species were found ubiquitously in all samples from the oral cavity to the distal colon. The dataset and its accompanying methodology may provide an important resource for future work investigating the biogeography of the mammalian gut virome.
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Terms governing use and reproduction
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Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Stockdale, Stephen R.
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9 (RLIN) 2043
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Personal name Lavelle, Aonghus
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9 (RLIN) 2044
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Personal name Kondova, Ivanela
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9 (RLIN) 2045
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Personal name Heuston, Cara
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9 (RLIN) 2046
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Personal name Upadrasta, Aditya
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9 (RLIN) 2047
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Personal name Khokhlova, Ekaterina V.
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9 (RLIN) 2048
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Personal name van der Kamp, Imme
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9 (RLIN) 2049
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Personal name Ouwerling, Boudewijn
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9 (RLIN) 2050
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Personal name Draper, Lorraine A.
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9 (RLIN) 2051
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Personal name Langermans, Jan A.M.
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9 (RLIN) 2052
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Personal name Ross, R Paul
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9 (RLIN) 2053
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Personal name Hill, Colin
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9 (RLIN) 2054
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Note Nat Microbiol
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1038/s41564-022-01178-w">http://dx.doi.org/10.1038/s41564-022-01178-w</a>
Public note Connect to this object online.

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