JOM KITA KE POLITEKNIK

LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma (Record no. 1830)

MARC details
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Authentication code dc
100 10 - MAIN ENTRY--PERSONAL NAME
Personal name Gur, Chamutal
Relator term author
9 (RLIN) 1055
245 00 - TITLE STATEMENT
Title LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma
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Date of publication, distribution, etc. 2022-04-14.
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General note /pmc/articles/PMC7612792/
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General note /pubmed/35381199
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Summary, etc. Systemic sclerosis (scleroderma, SSc) is an incurable autoimmune disease with high morbidity and mortality rates. Here, we conducted a population-scale single-cell genomic analysis of skin and blood samples of 56 healthy controls and 97 SSc patients at different stages of the disease. We found immune compartment dysfunction only in a specific subtype of diffuse SSc patients but global dysregulation of the stromal compartment, particularly in a previously undefined subset of LGR5(+)-scleroderma-associated fibroblasts (ScAFs). ScAFs are perturbed morphologically and molecularly in SSc patients. Single-cell multiome profiling of stromal cells revealed ScAF-specific markers, pathways, regulatory elements, and transcription factors underlining disease development. Systematic analysis of these molecular features with clinical metadata associates specific ScAF targets with disease pathogenesis and SSc clinical traits. Our high-resolution atlas of the sclerodermatous skin spectrum will enable a paradigm shift in the understanding of SSc disease and facilitate the development of biomarkers and therapeutic strategies.
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Wang, Shuang-Yin
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9 (RLIN) 1056
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Sheban, Fadi
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9 (RLIN) 1057
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Zada, Mor
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9 (RLIN) 1058
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Li, Baoguo
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9 (RLIN) 1059
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Personal name Kharouf, Fadi
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9 (RLIN) 1060
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Peleg, Hagit
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9 (RLIN) 1061
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Aamar, Suhail
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9 (RLIN) 1062
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Personal name Yalin, Adam
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9 (RLIN) 1063
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Personal name Kirschenbaum, Daniel
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9 (RLIN) 1064
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Personal name Braun-Moscovici, Yolanda
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9 (RLIN) 1065
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Personal name Jaitin, Diego Adhemar
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9 (RLIN) 1066
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Personal name meir-salame, Tomer
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9 (RLIN) 1067
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Hagai, Efrat
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9 (RLIN) 1068
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Kragesteen, Bjørt K.
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9 (RLIN) 1069
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Personal name Avni, Batia
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9 (RLIN) 1070
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Personal name Grisariu, Sigal
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9 (RLIN) 1071
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Personal name Bornstein, Chamutal
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9 (RLIN) 1072
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Personal name Shlomi-Loubaton, Shir
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9 (RLIN) 1073
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Personal name David, Eyal
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9 (RLIN) 1074
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Personal name Shreberk-Hassidim, Rony
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Personal name Molho-Pessach, Vered
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700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Amar, Dalit
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700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Tzur, Tomer
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9 (RLIN) 1078
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Personal name Kuint, Rottem
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9 (RLIN) 1079
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Personal name Gross, Moshe
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9 (RLIN) 1080
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Personal name Barboy, Oren
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9 (RLIN) 1081
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Personal name Moshe, Adi
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9 (RLIN) 1082
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Personal name Fellus-Alyagor, Liat
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9 (RLIN) 1083
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Personal name Hirsch, Dana
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9 (RLIN) 1084
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Personal name Addadi, Yoseph
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9 (RLIN) 1085
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Personal name Erenfeld, Shlomit
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9 (RLIN) 1086
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Personal name Biton, Moshe
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9 (RLIN) 1087
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Personal name Tzemach, Tehila
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9 (RLIN) 1088
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Personal name Elazary, Anat
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9 (RLIN) 1089
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Personal name Naparstek, Yaakov
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9 (RLIN) 1090
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Personal name Tzemach, Reut
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9 (RLIN) 1091
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Personal name Weiner, Assaf
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9 (RLIN) 1092
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Giladi, Amir
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9 (RLIN) 1093
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Personal name Balbir-Gurman, Alexandra
Relator term author
9 (RLIN) 1094
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Amit, Ido
Relator term author
9 (RLIN) 1095
786 0# - DATA SOURCE ENTRY
Note Cell
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1016/j.cell.2022.03.011">http://dx.doi.org/10.1016/j.cell.2022.03.011</a>
Public note Connect to this object online.

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