An MR fingerprinting approach for quantitative inhomogeneous magnetization transfer imaging (Record no. 1792)
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042 ## - AUTHENTICATION CODE | |
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Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | West, Daniel J. |
Relator term | author |
9 (RLIN) | 1894 |
245 00 - TITLE STATEMENT | |
Title | An MR fingerprinting approach for quantitative inhomogeneous magnetization transfer imaging |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2022-01-01. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7614010/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/34418151 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | PURPOSE: Magnetization transfer (MT) and inhomogeneous MT (ihMT) contrasts are used in MRI to provide information about macromolecular tissue content. In particular, MT is sensitive to macromolecules, and ihMT appears to be specific to myelinated tissue. This study proposes a technique to characterize MT and ihMT properties from a single acquisition, producing both semiquantitative contrast ratios and quantitative parameter maps. THEORY AND METHODS: Building on previous work that uses multiband RF pulses to efficiently generate ihMT contrast, we propose a cyclic steady-state approach that cycles between multiband and single-band pulses to boost the achieved contrast. Resultant time-variable signals are reminiscent of an MR fingerprinting acquisition, except that the signal fluctuations are entirely mediated by MT effects. A dictionary-based low-rank inversion method is used to reconstruct the resulting images and to produce both semiquantitative MT ratio and ihMT ratio maps, as well as quantitative parameter estimates corresponding to an ihMT tissue model. RESULTS: Phantom and in vivo brain data acquired at 1.5 Tesla demonstrate the expected contrast trends, with ihMT ratio maps showing contrast more specific to white matter, as has been reported by others. Quantitative estimation of semisolid fraction and dipolar T(1) was also possible and yielded measurements consistent with literature values in the brain. CONCLUSION: By cycling between multiband and single-band pulses, an entirely MT-mediated fingerprinting method was demonstrated. This proof-of-concept approach can be used to generate semiquantitative maps and quantitatively estimate some macromolecular-specific tissue parameters. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license. |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Cruz, Gastao |
Relator term | author |
9 (RLIN) | 1895 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Teixeira, Rui P. A. G. |
Relator term | author |
9 (RLIN) | 1896 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Schneider, Torben |
Relator term | author |
9 (RLIN) | 1897 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Tournier, Jacques-Donald |
Relator term | author |
9 (RLIN) | 1898 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Hajnal, Joseph V. |
Relator term | author |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Prieto, Claudia |
Relator term | author |
9 (RLIN) | 1900 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Malik, Shaihan J. |
Relator term | author |
9 (RLIN) | 1901 |
786 0# - DATA SOURCE ENTRY | |
Note | Magn Reson Med |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1002/mrm.28984">http://dx.doi.org/10.1002/mrm.28984</a> |
Public note | Connect to this object online. |
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