JOM KITA KE POLITEKNIK

Diffusion MR imaging acquisition and analytics for microstructural delineation in pre-clinical models of TBI (Record no. 1287)

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Personal name Harris, N.G.
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9 (RLIN) 418
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Title Diffusion MR imaging acquisition and analytics for microstructural delineation in pre-clinical models of TBI
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Date of publication, distribution, etc. 2022-05.
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General note /pmc/articles/PMC6824967/
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General note /pubmed/31044457
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Summary, etc. Significant progress has been made toward improving both the acquisition of clinical diffusion weighted imaging (DWI) data and its analysis in the uninjured brain, through various techniques including a large number of model-based solutions that have been proposed to fit for multiple tissue compartments, and multiple fibers per voxel. While some of these techniques have been applied to clinical traumatic brain injury (TBI) research, the majority of these technological enhancements have yet to be fully implemented in the pre-clinical arena of TBI animal model-based research. In this review we describe the requirement for pre-clinical, MRI-based efforts to provide systematic confirmation of the applicability of some of these models as indicators of tissue pathology within the injured brain. We review how current DWI techniques are currently being used in animal TBI models, and describe how both acquisition and analytic techniques could be extended to leverage the progress made in clinical work. Finally, we highlight remaining gaps in the pre-clinical pipeline from data acquisition to final analysis that currently have no real, pre-clinical-based correlate.
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Language note en
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Personal name Paydar, A.
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9 (RLIN) 419
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Personal name Smith, G.S.
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9 (RLIN) 420
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Personal name Lepore, S.
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9 (RLIN) 421
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Note J Neurosci Res
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1002/jnr.24416">http://dx.doi.org/10.1002/jnr.24416</a>
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